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Phase I study of BLU-285 in patients with GIST and other relapsed/refractory solid tumors.

Agents: BLU-285
Phase I
Status  Open, recruiting
Sponsor Blueprint Medicines Corporation

Further information:

WHO is the trial for?

  • Patients with confirmed diagnosis of unresectable GIST without a D842V mutation, that has progressed following imatinib and at least 1 of the following: sunitinib, regorafenib, sorafenib, dasatinib, pazopanib, or an experimental drug that targets KIT
  • Patients with a D842V mutation in the PDGFRA gene
  • Overall health status of the patient has to be good (ECOG performance status 0-2)

WHAT is the key question that this trial is attempting to answer?

This study assesses the safety and tolerability, but also the efficacy of BLU-285 in patients with unresectable GIST. This includes patients with a D842V mutation in the PDGFRA gene or those without that mutation which have progressed under at least two different TKI inhibitors.

WHY patients might want to participate?

This clinical trial offers patients an opportunity to access a new therapy strategy. This trial will further support the research in GIST and potentially help other patients with this disease. The trial might or might not have benefit in your individual case.

WHEN will the trial be open?

 The study is open (recruiting)

WHERE is the trial available?

The trial is available in several study centers in the US, Belgium, France, Germany, the Netherlands and the UK. For further information please check here.

Study contact:
Blueprint Medicines
Phone: +1-617-714-6707
E-Mail: このメールアドレスはスパムボットから保護されています。閲覧するにはJavaScriptを有効にする必要があります。

STUDY DESIGN: What does the study look like?

This study just contains one arm: All patients receive the study drug BLU-285. However, the study consists of 2 parts: Part 1 evaluates the dosage in which BLU-285 should be given, part 2 the efficacy of the drug.

HOW do I get more information?

Patient organisations supporting GIST and/or sarcoma patients in your country may offer additional information about the trial, current recruitment status, and key contacts. Click here for a list of patient organisations serving GIST and/or sarcoma patients. If there are no such organisation in your country, please email us for more information: このメールアドレスはスパムボットから保護されています。閲覧するにはJavaScriptを有効にする必要があります。

SHARE your experience

You want to share your experience on this trial?
Send us an e-mail to: このメールアドレスはスパムボットから保護されています。閲覧するにはJavaScriptを有効にする必要があります。
Note that your experience would be helpful for other patients and patient organisations.

RESULTS of the study

No results are available at this time. Future results will be linked here.


Disclaimer: This is a patient-friendly summary of the clinical trial which has been provided for informational purposes only. Patients should consult their physician about any clinical trial opportunity.


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